Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chahal, M.; Abdulkarim, B.; Xu, Y.; Guiot, M.C.; Easaw, J.C.; Stifani, N.; Sabri, S.
    O6-Methylguanine-DNA methyltransferase is a novel negative effector of invasion in glioblastoma multiforme (2012), Mol. Cancer Ther., 11, 2440-2450.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.63 expressed in U-87MG cells Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.63 21000
-
 x * 21000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.63 DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
 DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.63 A-172 cell
-
 Homo sapiens
-
2.1.1.63 LN-18 cell
-
 Homo sapiens
-
2.1.1.63 T-98G cell
-
 Homo sapiens
-
2.1.1.63 U-138 cell
-
 Homo sapiens
-
2.1.1.63 U-251 cell
-
 Homo sapiens
-
2.1.1.63 U-373 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA (containing 6-O-benzylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-benzylguanine) + protein S-benzyl-L-cysteine
-
 ?
2.1.1.63 DNA (containing 6-O-methylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.63 ? x * 21000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 MGMT
-
 Homo sapiens
2.1.1.63 O6-methylguanine-DNA methyltransferase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.63 physiological function the enzyme is a negative effector of glioblastoma multiforme invasion. Enzyme expression inversely correlates with angiogenesis and invasion in glioma Homo sapiens